Therapy should be prescribed only after critical benefit to risk appraisal in patients with a history of cardiac conduction disturbance, including second and third degree AV heart block; cardiac, hepatic, or renal damage; adverse hematologic or hypersensitivity reaction to other drugs, including reactions to other anticonvulsants; or interrupted courses of therapy with carbamazepine A recent scathing editorial in the Lancet took the FDA to task for its inappropriately close association with pharmaceutical companies
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